Antiplatelet Aggregation Activity of 4-phenyl-1,8- naphthyridine derivatives: Synthesis and Evaluation
نویسندگان
چکیده
A new series of 4-phenyl-1,8-naphthyridine derivative, substituted in position 6 and 7 were prepared and tested for their inhibitory effects on platelet aggregation by ADP, the most promising agent among them was2-(4'methoxybenzylamine)-6-amino-7-(piperidin-1-yl)-4-phenyl1,8-naphthyridine designated as14. The specificity of the inhibitory effects of 14 is presented by cycloalkyl amino moiety of the agent. Moreover, platelet aggregation induced by agonists other than ADP e.g., arachidonic acid, and collagen, was inhibited completely by compound 14. The analogues designated 12 and 13 showed a higher activity than that of 8-11 derivatives. Compounds 13 and 14 increased cAMP levels and significantly inhibited platelet aggregation. Muwaffag Badawneh and Jalal Aljamal* Faculty of Pharmacy, Jerash University, Jerash, Jordan. Submission: 7 May 2016 Accepted: 12 May 2016 Published: 25 May 2016 www.ijppr.humanjournals.com Citation: Jalal Aljamal et al. Ijppr.Human, 2016; Vol. 6 (2): 290-304. 29
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